Go Back   Professional Soldiers ® > TMC 14 > Vital Signs

Reply
 
Thread Tools Display Modes
Old 06-16-2012, 20:24   #1
Goon
SF Candidate
 
Join Date: Sep 2007
Location: Fort Bragg
Posts: 3
Tranexamic acid (txa)

Good morning Gentlemen,

I am curious as to any input the group has on the use of Tranexamic acid (txa) in the field real world. I have read the Crash study after talking to Mr. Proulx and Mr. Compton at TCMC and would like to know the real world application in the field and the opinion of the more educated than myself. I know as a non SOF medic it is out of the scope of practice for me but I am always trying to educate myself on new techniques and practices.

I understand the dosage, route and practical theory along with timelines to administer but hearing first hand usage accounts helps my understanding.

If I am out of line, I mean no disrespect.
__________________
"I don't want you to get hurt........., but I want to be there when you do!
Goon is offline   Reply With Quote
Old 08-02-2012, 14:48   #2
RockyFarr
Guest
 
Posts: n/a
TXA Use

Works better than Factor VIIa but needs to be given IV push in fluids before 3 hours after wounding.
  Reply With Quote
Old 08-12-2012, 08:57   #3
swatsurgeon
Guerrilla Chief
 
swatsurgeon's Avatar
 
Join Date: Jul 2004
Location: Phoenix, AZ
Posts: 880
Quote:
Originally Posted by RockyFarr View Post
Works better than Factor VIIa but needs to be given IV push in fluids before 3 hours after wounding.
Col.,
Welcome aboard, please add where ever you see fit.

Goon,
as mentioned has to be given <3 hrs from wounding...several issues from the two major studies done on the drug in Trauma (CRASH-2 and MATTERS trials)
- this is an antifibrinolytic......prevents breakdown of naturally occuring clot, so need clot for this to work and in the civilian world with aspirin, coumadin, plavix....no clot!!
- CRASH-2 study showed a 1.5% reduction in all cause mortality, over 20,000 patients in >200 hospitals in 40 countries.....see any potential problems yet??
The MATTERS trial, >900 patients treated at military facility in Afganistan with more severly injured and better results relative to survival benefit. Was a retrospective study and dosing was all over the place at the discretion of the treating team but usually given within 1 hr of wounding.
Our problem is the civilian world is not made up of young healthy, in shape soldiers with greater prehospital care available....give me an 18D ANYDAY!!!!! vs civilain EMS for the most part (just a generalized statement, don't shoot me for that one)
Benefits: low cost, longer window of opportunity it seems. Just don't know yet about our (civilian trauma) population efficacy.

Hope this helps

ss
__________________
'Revel in action, translate perceptions into instant judgements, and these into actions that are irrevocable, monumentous and dreadful - all this with lightning speed, in conditions of great stress and in an environment of high tension:what is expected of "us" is the impossible, yet we deliver just that.
(adapted from: Sherwin B. Nuland, MD, surgeon and author: The Wisdom of the Body, 1997 )

Education is the anti-ignorance we all need to better treat our patients. ss, 2008.

The blade is so sharp that the incision is perfect. They don't realize they've been cut until they're out of the fight: A Surgeon Warrior. I use a knife to defend life and to save it. ss (aka traumadoc)
swatsurgeon is offline   Reply With Quote
Reply


Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 
Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off

Forum Jump



All times are GMT -6. The time now is 06:02.



Copyright 2004-2022 by Professional Soldiers ®
Site Designed, Maintained, & Hosted by Hilliker Technologies