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InTheBlack · 03-11-2020, 08:14

Does "shedding after recovery" imply continued contagiousness?

And the other article said the highest viral load was reached in under 5 days, with an incubation period of 5.1 days. What is the definition of "incubation period?" Is it basically time to highest viral load? Or is COVID-19 unusual in this respect?

How do the above compare with seasonal flu or common cold?

What is "IQR" as a statistical term?

https://www.thelancet.com/lancet/art...736(20)30566-3
>
For survivors, the median duration of viral shedding
was 20·0 days (IQR 17·0–24·0) from illness onset, but the
virus was continuously detectable until death in nonsurvivors
(table 2; figure 1).

The shortest observed duration
of viral shedding among survivors was 8 days, whereas the
longest was 37 days.

Among 29 patients who received lopinavir/ritonavir and were discharged,
the median time from illness onset to initiation of antiviral treatment was
14·0 days (IQR 10·0–17·0) and
the median duration of viral shedding was 22·0 days (18·0–24·0).

The median duration of viral shedding was
19·0 days (17·0–22·0) in patients with severe disease status and

24·0 days (22·0–30·0) in patients with critical disease status.
>

http://www.cidrap.umn.edu/news-persp...vid-19-viruses

Study highlights ease of spread of COVID-19 viruses
Mar 09, 2020

COVID-19 can be spread before it causes symptoms, when it produces symptoms like those of the common cold, and as many as 12 days after recovery, according to a virologic analysis of nine infected patients published today on the preprint server medRxiv.

EDIT ADD LINK:
https://www.medrxiv.org/content/10.1...502v1.full.pdf
Virological assessment of hospitalized cases of coronavirus disease 2019 Wolfel

Also, in a study published in today's Annals of Internal Medicine, researchers at Johns Hopkins found a median incubation period for COVID-19 of 5.1 days—similar to that of severe acute respiratory syndrome (SARS).

https://annals.org/aim/fullarticle/2...licly-reported

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application Free
Lauer2020
...

in terms of viral load. "In SARS, it took 7 to 10 days after onset until peak RNA concentrations (of up to 5x105 copies per swab) were reached," the researchers wrote. "In the present study, peak concentrations were reached before day 5, and were more than 1,000 times higher."

03-11-2020, 08:14	#410
InTheBlack BANNED USER Join Date: May 2006 Posts: 249	Does "shedding after recovery" imply continued contagiousness? And the other article said the highest viral load was reached in under 5 days, with an incubation period of 5.1 days. What is the definition of "incubation period?" Is it basically time to highest viral load? Or is COVID-19 unusual in this respect? How do the above compare with seasonal flu or common cold? What is "IQR" as a statistical term? https://www.thelancet.com/lancet/art...736(20)30566-3 > For survivors, the median duration of viral shedding was 20·0 days (IQR 17·0–24·0) from illness onset, but the virus was continuously detectable until death in nonsurvivors (table 2; figure 1). The shortest observed duration of viral shedding among survivors was 8 days, whereas the longest was 37 days. Among 29 patients who received lopinavir/ritonavir and were discharged, the median time from illness onset to initiation of antiviral treatment was 14·0 days (IQR 10·0–17·0) and the median duration of viral shedding was 22·0 days (18·0–24·0). The median duration of viral shedding was 19·0 days (17·0–22·0) in patients with severe disease status and 24·0 days (22·0–30·0) in patients with critical disease status. > http://www.cidrap.umn.edu/news-persp...vid-19-viruses Study highlights ease of spread of COVID-19 viruses Mar 09, 2020 COVID-19 can be spread before it causes symptoms, when it produces symptoms like those of the common cold, and as many as 12 days after recovery, according to a virologic analysis of nine infected patients published today on the preprint server medRxiv. EDIT ADD LINK: https://www.medrxiv.org/content/10.1...502v1.full.pdf Virological assessment of hospitalized cases of coronavirus disease 2019 Wolfel Also, in a study published in today's Annals of Internal Medicine, researchers at Johns Hopkins found a median incubation period for COVID-19 of 5.1 days—similar to that of severe acute respiratory syndrome (SARS). https://annals.org/aim/fullarticle/2...licly-reported The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application Free Lauer2020 ... in terms of viral load. "In SARS, it took 7 to 10 days after onset until peak RNA concentrations (of up to 5x105 copies per swab) were reached," the researchers wrote. "In the present study, peak concentrations were reached before day 5, and were more than 1,000 times higher." Last edited by InTheBlack; 03-11-2020 at 08:32.
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