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InTheBlack · 02-20-2020, 12:57

I previously linked to this paper. I'd like to know more about the CD8+ T cell issue. Maybe the MD's here can read the citation & interpret?

https://www.frontiersin.org/articles...018.00343/full

Back to the Future: Lessons Learned From the 1918 Influenza Pandemic
Kirsty R. Short 1,2, Katherine Kedzierska3* and Carolien E. van de Sand
2018

>
MEDICAL INTERVENTIONS, THERAPIES AND VACCINES: THEN AND NOW
snip

Unfortunately, antibodies elicited by seasonal
influenza vaccines do not provide protection in the case of an
antigenically distinct influenza virus of a novel subtype, such
as A/H5N1 or A/H7N9 (De Jong et al., 2000). Furthermore,
current inactivated seasonal influenza vaccines may even prevent
the induction of cross-reactive CD8+ T cell responses, which
are our primary protection in case of a pandemic outbreak
and may therefore prove to be a double-edged sword (Bodewes
et al., 2009a,b, 2011b,c).

02-20-2020, 12:57	#190
InTheBlack BANNED USER Join Date: May 2006 Posts: 249	Getting a flu shot may be the wrong strategy? I previously linked to this paper. I'd like to know more about the CD8+ T cell issue. Maybe the MD's here can read the citation & interpret? https://www.frontiersin.org/articles...018.00343/full Back to the Future: Lessons Learned From the 1918 Influenza Pandemic Kirsty R. Short 1,2, Katherine Kedzierska3* and Carolien E. van de Sand 2018 > MEDICAL INTERVENTIONS, THERAPIES AND VACCINES: THEN AND NOW snip Unfortunately, antibodies elicited by seasonal influenza vaccines do not provide protection in the case of an antigenically distinct influenza virus of a novel subtype, such as A/H5N1 or A/H7N9 (De Jong et al., 2000). Furthermore, current inactivated seasonal influenza vaccines may even prevent the induction of cross-reactive CD8+ T cell responses, which are our primary protection in case of a pandemic outbreak and may therefore prove to be a double-edged sword (Bodewes et al., 2009a,b, 2011b,c).
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