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InTheBlack · 02-04-2020, 02:07

Mug - Prayers for you. Don't ring the bell !!! You still have knowledge, you can still do good.

Questions for all:

I don't know the difference between ACE1 and ACE2, but reading indicates ACE2 is the choice. I thought the ACE2 class was a commonly used oral drug? If so, what are some brand & generic names? Or is it still a researchers' unicorn ?

I have dug out my notes from October 2006 in the Pandemic Flu thread.

Statins, like Zocor, 20mg twice a day at first hint of symptoms, and once a day for family members who are asymptomatic. Seems like 10-12 day course probably reasonable risk.

ACE2 seemed to be "new" vs flu in 2006 -- No dosage info.

By now, doesn't WHO etc have a medical protocol for treating SARS & MERS etc which specifies drugs & dosage etc ? I am searching but the web is full of spam; need to find a portal to real physician information.

Wondering if "vasodilatory shock" is synonymous with ARDS (acute respiratory distress syndrome). Not sure if this article contains useful knowledge:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067786/
Angiotensin II: a new therapeutic option for vasodilatory shock

Angiotensin II (Ang II), part of the renin–angiotensin–aldosterone system (RAS), is a potent vasoconstrictor and has been recently approved for use by the US Food and Drug Administration in high-output shock.

Though not a new drug, the recently published Angiotensin II for the Treatment of High Output Shock (ATHOS-3) trial, as well as a number of retrospective analyses have sparked renewed interest in the use of Ang II, which may have a role in treating refractory shock.

We describe refractory shock, the unique mechanism of action of Ang II, RAS dysregulation in shock, and the evidence supporting the use of Ang II to restore blood pressure.

Evidence suggests that Ang II may preferentially be of benefit in acute kidney injury and acute respiratory distress syndrome, where the RAS is known to be disrupted.

Additionally, there may be a role for Ang II in cardiogenic shock, angiotensin converting enzyme inhibitor overdose, cardiac arrest, liver failure, and in settings of extracorporeal circulation.
********

Don't know about dehydration & fluids. How many liters of IV bags might be needed? What type of fluid? Is subcutaneous administration feasible in adults (I know how to do that).

Goldpharma.com still exists, but maybe it only allows drug searches if you register first. I can't get anything but the home page to show.

02-04-2020, 02:07	#36
InTheBlack BANNED USER Join Date: May 2006 Posts: 249	Mug - Prayers for you. Don't ring the bell !!! You still have knowledge, you can still do good. Questions for all: I don't know the difference between ACE1 and ACE2, but reading indicates ACE2 is the choice. I thought the ACE2 class was a commonly used oral drug? If so, what are some brand & generic names? Or is it still a researchers' unicorn ? I have dug out my notes from October 2006 in the Pandemic Flu thread. Statins, like Zocor, 20mg twice a day at first hint of symptoms, and once a day for family members who are asymptomatic. Seems like 10-12 day course probably reasonable risk. ACE2 seemed to be "new" vs flu in 2006 -- No dosage info. By now, doesn't WHO etc have a medical protocol for treating SARS & MERS etc which specifies drugs & dosage etc ? I am searching but the web is full of spam; need to find a portal to real physician information. Wondering if "vasodilatory shock" is synonymous with ARDS (acute respiratory distress syndrome). Not sure if this article contains useful knowledge: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067786/ Angiotensin II: a new therapeutic option for vasodilatory shock Angiotensin II (Ang II), part of the renin–angiotensin–aldosterone system (RAS), is a potent vasoconstrictor and has been recently approved for use by the US Food and Drug Administration in high-output shock. Though not a new drug, the recently published Angiotensin II for the Treatment of High Output Shock (ATHOS-3) trial, as well as a number of retrospective analyses have sparked renewed interest in the use of Ang II, which may have a role in treating refractory shock. We describe refractory shock, the unique mechanism of action of Ang II, RAS dysregulation in shock, and the evidence supporting the use of Ang II to restore blood pressure. Evidence suggests that Ang II may preferentially be of benefit in acute kidney injury and acute respiratory distress syndrome, where the RAS is known to be disrupted. Additionally, there may be a role for Ang II in cardiogenic shock, angiotensin converting enzyme inhibitor overdose, cardiac arrest, liver failure, and in settings of extracorporeal circulation. ******** Don't know about dehydration & fluids. How many liters of IV bags might be needed? What type of fluid? Is subcutaneous administration feasible in adults (I know how to do that). Goldpharma.com still exists, but maybe it only allows drug searches if you register first. I can't get anything but the home page to show.
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