[PedOncoDoc]

Originally Posted by PrimalAndrew

Interestingly, for people with some coagulopathies, this type of material might not activate the coagulation cascade (Hemophilia A, Hemophilia B, Inhibitor mutations, Factor 5 Leiden). For others this miiiight do such a thing (Factor 13th deficiency, Lupus Anticoagulant, van Willebrand's disease...)

Having something to act as skin to stop bleeding, may be useful though.

Factor V Leiden is not a coagulopathy - most the time it's not even a thrombophilic condition, although in the homozygous form (and on occasion in the heterozygous case with likely other genetic modifiers) can cause blood clots. Also - what "inhibitor mutations" are you speaking about? Inhibitors typically either arise spontaneously in healthy individuals and are typically transient, or develop in patients who do not make a specific clotting factor (most classically against FVIII in Hemophilia A).

Get your facts straight before adding medical/scientific opinions on subjects.

ECM serves as an initiator for platelet plug formation, and platelet-platelet binding is facilitated through von Willebrand factor which leads to the platelet plug. The coagulation cascade leads to fibrin deposition and crosslinking which makes the stable clot.

This product would be unlikely to work in patients with inherent platelet defects (e.g. Glanzman's thrombasthenia or Bernard-Soulier) or von Willebrand's disease (type 2s, type 3, and severe Type 1s due to the inability to make a primary platelet plug, and any moderate-to-severe factor deficiency that culminates in bleeding due to the inability to make a stable clot, although the latter would have temporary cessation of bleeding only to have recurrence later.