I've run with an M&P 45fs in a SmartCarry holster with great comfort. The weight is centered on your frame so no torque is induced. The downside is that it does not provide very fast access. Then again, I don't run where I see snakes.
If you decide to try one, buy it from their web site as Charlie will give you 60 days to evaluate it if you buy it from him instead of a distributor.
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