I've gotten some great laughs out of kids who were getting colonoscopies under conscious sedation.
One kid decided tro serenade us with his favorite Wierd Al Yankovic songs - Yoda and Amish Paradise.
A young man asked if we wee going to leave anything in there for him to find later - kind of like a surprise in a cracker jack box.
One particular wiseass started singing Zappa - "Ram it, Ram it, Ram it, Ram it up your poop shoot".
The danger of shap wit during a procedure is that it can get a bit more uncoformatable if the "driver" of the colonoscope starts laughing so hard they they aren't controllingthe scope as well as they could... 
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"The dignity of man is not shattered in a single blow, but slowly softened, bent, and eventually neutered. Men are seldom forced to act, but are constantly restrained from acting. Such power does not destroy outright, but prevents genuine existence. It does not tyrannize immediately, but it dampens, weakens, and ultimately suffocates, until the entire population is reduced to nothing better than a flock of timid, uninspired animals, of which the government is shepherd." - Alexis de Tocqueville
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