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Ivermectin ??
Ivermectin - Maybe one solution??
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https://www.stagvetsinc.org/ Quote:
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Sadly, I agree completely!!! |
I'm just wondering how many old school drugs will be effective on this virus - and then find out they would have been effective against other SARS/MERS type stuff?
But they were never looked at because there is no money in old drugs. Link to JJ's story https://www.msn.com/en-au/news/coron...7Ux?li=AAgfYrC |
I have no doubt that could be the case. Just short of completely manufactured viruses, I believe what Solomon said many years ago..."There is nothing new under the sun." Mutations happen but there are a lot of existing drugs out there that could be effective against this virus, but those way smarter than I have to be willing to look at them -- much like some are.
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Dr Ralph Baric is the foremost thought leader on corona viruses. The following is the definitive word on this subject IMO
https://www.bing.com/videos/search?q...6FORM%3DVDVVXX |
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That is something I've wondered about as well. One thing I learned while working in the industry is that no one really does a negative screen on small molecule compounds. They look for compounds that are lets say are specific for one protein in a pathway that they are trying to target. They'll examine the SAR (structure activity relationships) for the few compounds that look promising.Then, they'll ask themselves if it binds to anything else in that pathway by generating knockouts for that protein in a cell line that they chose for screening and also do binding assays which all take a very long time. If the answer is no and there is no toxicity to healthy cells, then they move further to mouse studies and then eventually to humans. They will not try to do binding assays with the small molecule on any protein that is not involved in some way with the target of interest simply because they are curious. It comes down to how many people you have on your team and how much time you have to finish a project. This is why you get compounds that are essentially multi-purpose but are not known because they have not been evaluated before they hit the drug market. |
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But there are a million plus doctors able to prescribe in the US. In a country with a long history of innovation. Fuelled by an unmatched H-hour sense of urgency combined with recent/accessible machine learning tools to support rapid pattern recognition and discovery of reformulated back catalog drug efficacy. I’m hopeful a few docs and a few nerds with a few bucks can find something effective and fast. |
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On a serious note, why is it we don’t have a vaccine from 2002 and 2003 SARS, 2005 MERS or 2009 Versions of coronavirus? Why is this time different? Why is this time DIFFERENT? |
Well, today's updates have been posted and daily new cases and daily new deaths are both down.
Looking at the hockey stick graphs none of them have the sharp rocketing up everyone was predicting three weeks ago. https://www.worldometers.info/coronavirus/country/us/ |
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They didn't last long enough to be a pandemic threat; MERS 214 cases, SARS total 8,000 cases, so no vaccine was developed. NO $$$ in it. |
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This may not last very long either but damn it sure is costing $$$ and lives that may have not become a pandemic had someone created a vaccine for “coronavirus” and only needed tweaking for each different protein spikes. This isn’t rocket science, it’s medicine! |
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