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JJ_BPK 04-04-2020 07:55

Ivermectin ??
 
Ivermectin - Maybe one solution??


Quote:

Coronavirus Australia: Ivermectin, Anti-parasitic drug kills COVID-19 in lab, Christine McGinn, AAP, news.com.auApril 4, 20207:58am

A single dose of an anti-parasitic drug could essentially remove all genetic material of the COVID-19 virus within 48 hours, an Australian-led study has shown,

An anti-parasitic drug available throughout the world has been found to kill COVID-19 in the lab within 48 hours.

A Monash University-led study has shown a single dose of the drug Ivermectin could stop the SARS-CoV-2 virus growing in cell culture.

“We found that even a single dose could essentially remove all viral RNA (effectively removed all genetic material of the virus) by 48 hours and that even at 24 hours there was a really significant reduction in it,” Monash Biomedicine Discovery Institute’s Dr Kylie Wagstaff said on Friday.
link:
Jon owns Comfort Farms
https://www.stagvetsinc.org/

Quote:


Jon Jackson
3 hrs ·

Ivermectin is the only drug I give my pigs. When they are born and weaned I give them a shot to kill any parasites. They go into the socialization pen and before sending them to the market pen they get one more shot. Some folks point out that your herd can never be Organic with the use of this Anti-parasitic drug... But that's ok. When your animals free range they are exposed to nature and everything wants to survive. To include parasites. But they don't stand a chance with Ivomect. To hear and read how this can potentially be the answer for Covid is amazing. People ask me all the time... What should I invest in? I say invest in Agriculture. Invest in your local farmers. If they thrive... You thrive!

doctom54 04-04-2020 09:03

Quote:

Originally Posted by mugwump (Post 657617)
.......

The only way this ends, the only way, is when the susceptible population goes away: illness followed by immunity or death, or an effective vaccine. If you flatten the curve through isolation the disease pops up again as soon as you loosen up. But there's no other option except to let it rip through the population. And that’s politically impossible.

We'll see another serious wave this fall for that exact reason.


Sadly, I agree completely!!!

Pete 04-04-2020 09:04

I'm just wondering how many old school drugs will be effective on this virus - and then find out they would have been effective against other SARS/MERS type stuff?

But they were never looked at because there is no money in old drugs.

Link to JJ's story

https://www.msn.com/en-au/news/coron...7Ux?li=AAgfYrC

Sohei 04-04-2020 09:34

I have no doubt that could be the case. Just short of completely manufactured viruses, I believe what Solomon said many years ago..."There is nothing new under the sun." Mutations happen but there are a lot of existing drugs out there that could be effective against this virus, but those way smarter than I have to be willing to look at them -- much like some are.

doctom54 04-04-2020 10:22

Quote:

Originally Posted by Badger52 (Post 657533)
....Bac-si....:)

Thanks is has been 40 years since anyone called me that.

Trapper John 04-04-2020 17:49

Dr Ralph Baric is the foremost thought leader on corona viruses. The following is the definitive word on this subject IMO

https://www.bing.com/videos/search?q...6FORM%3DVDVVXX

Wiseman 04-04-2020 22:13

Quote:

Originally Posted by Pete (Post 657674)
I'm just wondering how many old school drugs will be effective on this virus - and then find out they would have been effective against other SARS/MERS type stuff?

But they were never looked at because there is no money in old drugs.

Link to JJ's story

https://www.msn.com/en-au/news/coron...7Ux?li=AAgfYrC


That is something I've wondered about as well. One thing I learned while working in the industry is that no one really does a negative screen on small molecule compounds. They look for compounds that are lets say are specific for one protein in a pathway that they are trying to target. They'll examine the SAR (structure activity relationships) for the few compounds that look promising.Then, they'll ask themselves if it binds to anything else in that pathway by generating knockouts for that protein in a cell line that they chose for screening and also do binding assays which all take a very long time. If the answer is no and there is no toxicity to healthy cells, then they move further to mouse studies and then eventually to humans. They will not try to do binding assays with the small molecule on any protein that is not involved in some way with the target of interest simply because they are curious. It comes down to how many people you have on your team and how much time you have to finish a project. This is why you get compounds that are essentially multi-purpose but are not known because they have not been evaluated before they hit the drug market.

Flagg 04-05-2020 02:24

Quote:

Originally Posted by Pete (Post 657674)
I'm just wondering how many old school drugs will be effective on this virus - and then find out they would have been effective against other SARS/MERS type stuff?

But they were never looked at because there is no money in old drugs.

Link to JJ's story

https://www.msn.com/en-au/news/coron...7Ux?li=AAgfYrC

I’m certainly no doctor.

But there are a million plus doctors able to prescribe in the US.

In a country with a long history of innovation.

Fuelled by an unmatched H-hour sense of urgency combined with recent/accessible machine learning tools to support rapid pattern recognition and discovery of reformulated back catalog drug efficacy.

I’m hopeful a few docs and a few nerds with a few bucks can find something effective and fast.

Razor 04-05-2020 17:52

Quote:

Originally Posted by Trapper John (Post 657690)
Dr Ralph Baric is the foremost thought leader on corona viruses.

Is that an on-line certificate, or do you have to go through the Dept. of Education for that title?

Old Dog New Trick 04-05-2020 19:32

Quote:

Originally Posted by Razor (Post 657715)
Is that an on-line certificate, or do you have to go through the Dept. of Education for that title?

I got mine when I finished 300-F1. In fact every 18D leaves SOMC with the knowledge to not only win the hearts and minds but save their teammates from every conceivable illness or injury - and sometimes they just can.

On a serious note, why is it we don’t have a vaccine from 2002 and 2003 SARS, 2005 MERS or 2009 Versions of coronavirus? Why is this time different?

Why is this time DIFFERENT?

Pete 04-05-2020 20:02

Well, today's updates have been posted and daily new cases and daily new deaths are both down.

Looking at the hockey stick graphs none of them have the sharp rocketing up everyone was predicting three weeks ago.

https://www.worldometers.info/coronavirus/country/us/

doctom54 04-05-2020 20:22

Quote:

Originally Posted by Old Dog New Trick (Post 657721)
On a serious note, why is it we don’t have a vaccine from 2002 and 2003 SARS, 2005 MERS or 2009 Versions of coronavirus? Why is this time different?

Why is this time DIFFERENT?


They didn't last long enough to be a pandemic threat; MERS 214 cases, SARS total 8,000 cases, so no vaccine was developed.

NO $$$ in it.

Old Dog New Trick 04-05-2020 20:29

Quote:

Originally Posted by doctom54 (Post 657723)
They didn't last long enough to be a pandemic threat; so no vaccine was developed.

NO $$$ in it.

Thanks Tom,

This may not last very long either but damn it sure is costing $$$ and lives that may have not become a pandemic had someone created a vaccine for “coronavirus” and only needed tweaking for each different protein spikes.

This isn’t rocket science, it’s medicine!

WarriorDiplomat 04-05-2020 20:54

Quote:

Originally Posted by doctom54 (Post 657723)
They didn't last long enough to be a pandemic threat; MERS 214 cases, SARS total 8,000 cases, so no vaccine was developed.

NO $$$ in it.

The bottom line


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