https://www.cell.com/cell/fulltext/S...674(20)30103-3
Click on the NK cell maturation graphic so you can watch the video and don't have to read Carl.
OK youse guys, gather around and take a knee. Smoke 'em if you got 'em!
The problem with this whole pandemic think issue is the absence of adequate medical counter-measures! Why is that you ask? Excellent question, Carl.
Every time a new antibiotic resistant bacterium emerges we go into a full-blown panic to develop a new antibiotic. Same with a new virus with pandemic potential. Rush to develop a new vaccine- e.g. the excitement surrounding the newly discovered "spike protein on the virus.
I call this the "see bug- kill bug approach. So what's wrong with that? Sit down Carl and pay attention.
Overuse and misuse of antibiotics induces antibiotic resistance. So developing new antibiotics to combat antibiotic resistant bacteria is merely repeating the same experiment while expecting a different outcome.
Humans have been confronted with these challenges over millions of years of evolution and yet here we are. The better question is what are the natural defense mechanisms and how can they be pharmaceutically exploited to provide resistance?
Vaccine development is one strategy. Exploiting the innate arm of the immune response (see link provided above) is another. We are still in the infancy of being able to fully exploit this strategy. I published a paper in 2012 that is the first such attempt. We are continuing to push the envelope on this. [NLRP3 Inflammasome is a Target for Development of Broad-Spectrum Anti-Infective Drugs Antimicrob. Agents Chemother. 2012, 56(4):1921. Carol M. Artlett, Sihem Sassi-Gaha, Mitali Purohit, Richard F. Rest and James D. Thacker]
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