04-04-2020, 09:04
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#811
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Quiet Professional
Join Date: Feb 2005
Location: Fayetteville
Posts: 13,080
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I'm just wondering how many old school drugs will be effective on this virus - and then find out they would have been effective against other SARS/MERS type stuff?
But they were never looked at because there is no money in old drugs.
Link to JJ's story
https://www.msn.com/en-au/news/coron...7Ux?li=AAgfYrC
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Pete is offline
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04-04-2020, 09:34
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#812
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Area Commander
Join Date: Dec 2010
Posts: 1,690
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I have no doubt that could be the case. Just short of completely manufactured viruses, I believe what Solomon said many years ago..."There is nothing new under the sun." Mutations happen but there are a lot of existing drugs out there that could be effective against this virus, but those way smarter than I have to be willing to look at them -- much like some are.
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Sohei is offline
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04-04-2020, 10:22
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#813
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Quiet Professional
Join Date: Feb 2009
Location: Northwest AR
Posts: 490
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Quote:
Originally Posted by Badger52
....Bac-si....  |
Thanks is has been 40 years since anyone called me that.
__________________
"For exercise I recommend vigorous walking... and carrying a gun. The gun’s weight will increase the level of exercise and the possession of a gun on a walk produces real confidence."
Thomas Jefferson
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doctom54 is offline
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04-04-2020, 17:49
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#814
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Quiet Professional
Join Date: Nov 2012
Location: Harrisburg, PA
Posts: 3,834
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Dr Ralph Baric is the foremost thought leader on corona viruses. The following is the definitive word on this subject IMO
https://www.bing.com/videos/search?q...6FORM%3DVDVVXX
__________________
Honor Above All Else
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Trapper John is offline
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04-04-2020, 22:13
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#815
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Guerrilla Chief
Join Date: Jan 2004
Location: New York
Posts: 505
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Quote:
Originally Posted by Pete
I'm just wondering how many old school drugs will be effective on this virus - and then find out they would have been effective against other SARS/MERS type stuff?
But they were never looked at because there is no money in old drugs.
Link to JJ's story
https://www.msn.com/en-au/news/coron...7Ux?li=AAgfYrC |
That is something I've wondered about as well. One thing I learned while working in the industry is that no one really does a negative screen on small molecule compounds. They look for compounds that are lets say are specific for one protein in a pathway that they are trying to target. They'll examine the SAR (structure activity relationships) for the few compounds that look promising.Then, they'll ask themselves if it binds to anything else in that pathway by generating knockouts for that protein in a cell line that they chose for screening and also do binding assays which all take a very long time. If the answer is no and there is no toxicity to healthy cells, then they move further to mouse studies and then eventually to humans. They will not try to do binding assays with the small molecule on any protein that is not involved in some way with the target of interest simply because they are curious. It comes down to how many people you have on your team and how much time you have to finish a project. This is why you get compounds that are essentially multi-purpose but are not known because they have not been evaluated before they hit the drug market.
Last edited by Wiseman; 04-05-2020 at 00:45.
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Wiseman is offline
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04-05-2020, 02:24
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#816
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Area Commander
Join Date: May 2011
Location: New Zealand
Posts: 1,423
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Quote:
Originally Posted by Pete
I'm just wondering how many old school drugs will be effective on this virus - and then find out they would have been effective against other SARS/MERS type stuff?
But they were never looked at because there is no money in old drugs.
Link to JJ's story
https://www.msn.com/en-au/news/coron...7Ux?li=AAgfYrC |
I’m certainly no doctor.
But there are a million plus doctors able to prescribe in the US.
In a country with a long history of innovation.
Fuelled by an unmatched H-hour sense of urgency combined with recent/accessible machine learning tools to support rapid pattern recognition and discovery of reformulated back catalog drug efficacy.
I’m hopeful a few docs and a few nerds with a few bucks can find something effective and fast.
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Flagg is offline
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04-05-2020, 17:52
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#817
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Quiet Professional
Join Date: Jan 2004
Location: Colorado Springs
Posts: 4,510
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Quote:
Originally Posted by Trapper John
Dr Ralph Baric is the foremost thought leader on corona viruses.
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Is that an on-line certificate, or do you have to go through the Dept. of Education for that title?
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Razor is offline
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04-05-2020, 19:32
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#818
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Quiet Professional
Join Date: Mar 2011
Location: Just above the flood plain in Southern Texas
Posts: 3,608
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Quote:
Originally Posted by Razor
Is that an on-line certificate, or do you have to go through the Dept. of Education for that title?
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I got mine when I finished 300-F1. In fact every 18D leaves SOMC with the knowledge to not only win the hearts and minds but save their teammates from every conceivable illness or injury - and sometimes they just can.
On a serious note, why is it we don’t have a vaccine from 2002 and 2003 SARS, 2005 MERS or 2009 Versions of coronavirus? Why is this time different?
Why is this time DIFFERENT?
__________________
You only live once; live well. Have no regrets when the end happens!
“The only thing necessary for the triumph of evil is for good men to do nothing.” (Sir Edmund Burke)
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Old Dog New Trick is offline
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04-05-2020, 20:02
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#819
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Quiet Professional
Join Date: Feb 2005
Location: Fayetteville
Posts: 13,080
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Well, today's updates have been posted and daily new cases and daily new deaths are both down.
Looking at the hockey stick graphs none of them have the sharp rocketing up everyone was predicting three weeks ago.
https://www.worldometers.info/coronavirus/country/us/
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Pete is offline
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04-05-2020, 20:22
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#820
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Quiet Professional
Join Date: Feb 2009
Location: Northwest AR
Posts: 490
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Quote:
Originally Posted by Old Dog New Trick
On a serious note, why is it we don’t have a vaccine from 2002 and 2003 SARS, 2005 MERS or 2009 Versions of coronavirus? Why is this time different?
Why is this time DIFFERENT?
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They didn't last long enough to be a pandemic threat; MERS 214 cases, SARS total 8,000 cases, so no vaccine was developed.
NO $$$ in it.
__________________
"For exercise I recommend vigorous walking... and carrying a gun. The gun’s weight will increase the level of exercise and the possession of a gun on a walk produces real confidence."
Thomas Jefferson
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doctom54 is offline
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04-05-2020, 20:29
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#821
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Quiet Professional
Join Date: Mar 2011
Location: Just above the flood plain in Southern Texas
Posts: 3,608
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Quote:
Originally Posted by doctom54
They didn't last long enough to be a pandemic threat; so no vaccine was developed.
NO $$$ in it.
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Thanks Tom,
This may not last very long either but damn it sure is costing $$$ and lives that may have not become a pandemic had someone created a vaccine for “coronavirus” and only needed tweaking for each different protein spikes.
This isn’t rocket science, it’s medicine!
__________________
You only live once; live well. Have no regrets when the end happens!
“The only thing necessary for the triumph of evil is for good men to do nothing.” (Sir Edmund Burke)
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Old Dog New Trick is offline
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04-05-2020, 20:54
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#822
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Quiet Professional
Join Date: May 2010
Location: C.S. Colorado
Posts: 2,021
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Quote:
Originally Posted by doctom54
They didn't last long enough to be a pandemic threat; MERS 214 cases, SARS total 8,000 cases, so no vaccine was developed.
NO $$$ in it.
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The bottom line
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“For the strength of the Pack is the Wolf, and the strength of the Wolf is the Pack.” –Rudyard Kipling, The Law of the Jungle, The Jungle Book.
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WarriorDiplomat is offline
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04-06-2020, 03:36
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#823
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Area Commander
Join Date: Nov 2004
Location: Lone Star
Posts: 2,153
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Quote:
Originally Posted by Badger52
Possibly a "social impact" question but I wonder how much their culture plays into their cooperation in that matter, and how much the ego-driven rugged individualized nature of ours hinders it.
NB: I do NOT have a 1st Aid Merit badge from the BSA so h/t JJ.
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IMHOO that is spot on.
The face-saving-collective-over-individual mindset heavily influences the mass wearing of masks. In those Eastern countries, you don’t want to inflict your sickness to others. Thus you wear a mask even if unsure/asymptomatic. In the West, we want the sick to wear mask so there’s a stigma associated with mask wearing. Instead of being seen as a thoughtful individual, you are a sick 🤒 person walking around. A solid example of cultural shift in mask wearing is in Czech Republic
https://www.google.com.pk/amp/s/amp....ee-coronavirus
I guess not only they make solid pistols and Bren .... 
Now their homemade masks are
Top tier in volume (n hopefully quality too)
__________________
"we also rejoice in our sufferings, because we know that suffering produces perseverance; perseverance, character; and character, hope" Rom. 5:3-4
"So we can suffer, and in suffering we know who we are" David Goggins
"Aide-toi, Dieu t'aidera " Jehanne, la Pucelle
Der, der Geld verliert, verliert einiges;
Der, der einen Freund verliert, verliert viel mehr;
Der, der das Vertrauen verliert, verliert alles.
INDNJC
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frostfire is offline
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04-06-2020, 13:23
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#824
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Quiet Professional
Join Date: Feb 2007
Location: Occupied America....
Posts: 4,740
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Boris Johnson to ICU
Quote:
Prime Minister Boris Johnson has been taken into intensive care in hospital with coronavirus.
He has asked Foreign Secretary Dominic Raab to deputise for him, a No 10 spokesman said.
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First world leader??
From BBC
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"There are more instances of the abridgment of freedom of the people by gradual and silent encroachments of those in power than by violent and sudden usurpations"
James Madison
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Ret10Echo is offline
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04-06-2020, 13:42
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#825
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Quiet Professional
Join Date: Apr 2008
Location: 18 yrs upstate NY, 30 yrs South Florida, 20 yrs Conch Republic, now chasing G-Kids in NOVA & UK
Posts: 11,901
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Quote:
Originally Posted by Ret10Echo
Boris Johnson to ICU
First world leader??
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Boris is out-going, gregarious, and very social
and QE II is still pissed he won the election.
I wonder if she sent Charley to visit #10?
__________________
Go raibh tú leathuair ar Neamh sula mbeadh a fhios ag an diabhal go bhfuil tú marbh
"May you be a half hour in heaven before the devil knows you’re dead"
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JJ_BPK is offline
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