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I was on Mefloquine for a JCET to Tchad back in '05. Our medic took me off of it because I started having some "anger issues." At one point I can remember being in my hotel room in a rage kicking the crap out of the door to the room because I could hear the music from the live band out back. It wasn't particularly loud or obnoxious but for some reason it made me really angry. That, and a few irrational outbursts were enough to get me pulled off of the Mefloquine and swtched to Doxy, which gave me a horrible sunburn but cut back sharply on the irrational anger.
I recently deployed to another malaria zone and was put on Doxy because to get on Meflequine now you have to have a documented reaction to Doxy. It was fine at first but then I had a reaction to the Doxy that I wrote off as not having eaten with the dose but then it happened again even though I had eaten this time. This reaction, in addition to the severe nausea of the first reaction, included vomiting, dizziness and some mild paresthesia in my lips and fingers. After that I was switched to Malarone, which still causes nausea if I don't eat with it but that is it.
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